HME/TSP Training Module

Hot Melt Extrusion /Twin Screw Processing:

Hot Melt Extrusion or Twin Screw Processing has widely accepted method for continuous processing of pharmaceuticals or other healthcare products with significant advantages compared to batch process. This technology has been proven for solid dispersion, Wet & Melt Granulation, Transdermal, Implants and many more applications.

To fully utilize and get the advantages of this Technology, a better understanding through a training is required.

Swalava team has more than 10 years of experience in this technology. Through various modules we provide training of this technology via class room or Hands on Experience. This training will be helpful to R&D, Production and Quality departments.

Note: Based on the company’s needs and objective, we work out a customized training schedule and provide the training at customer site.

Training module:

Module I - BASICS OF HME/TSP

• Details of machine and its various components
• Process parameters and its role in
• Polymer used & Formulation aspects,
• Application of HME
• Q&A

Module II- ADVANCE OF HME/TSP

• HME processing conditions and its impact on product development.
• (Process variables - Specific energy influence /Screw speed/Motor load (Torque) /Temperature profile influence of the various operating parameters)
• Drug properties impacting the processing.
• Polymer Selection
• Process : Solid Dispersion and Continuous Granulation
• Various Application
• Scale-up and various aspect to be considered
• Regulatory prospects on continuous processing.
• Various Upstream and Downstream accessories.
• Q&A

Module III- HANDS ON TRAINING ON THE EQUIPMENT

• Assembling of Equipment with screw configuration setup.
• Procedure for Start-up
• Placebo Process demonstration
• Trouble shooting - Operating window - Torque limitations - Melting limitations - Vent limitations - Feed limitations - Pressure limitations
• Q&A
• Evaluation based on case studies